[Seminario lunedi 25 feb 2019 ore 14] A. Esposito ... Subject: [Seminario lunedi 25 feb 2019 ore 14] A. Esposito - Chromatin architecture code inferred by machine learning and polymer physics From: "eneagrid administrators" Date: 14/02/19, 15:57 To: griduser Buongiorno, lunedi 25 febbraio 2019, alle ore 14.00, Andrea Esposito terra un seminario dal titolo "Chromatin architecture code inferred by machine learning and polymer physics". Il seminario sara trasmesso online via Connect al seguente indirizzo: https://connect.portici.enea.it/hpc Andrea e uno studente dell'Universita di Napoli "Federico II" e lavora nel gruppo "Sistemi Complessi" del prof. Mario Nicodemi. =================== Good morning, on Monday 25 February 2019 at 14:00 Andrea Esposito will hold a seminar entitled "Chromatin architecture code inferred by machine learning and polymer physics". The seminar will be transmitted via web via Connect at the following link: https://connect.portici.enea.it/hpc . Andrea is a student of the Napoles University "Fedrico II" and works in the "Complex Systems" team of prof. Mario Nicodemi. ************************* ABSTRACT ************************************ [Chromatin architecture code inferred by machine learning and polymer physics] The genome has a complex 3D organization, serving key functional purposes, yet the nature of the factors shaping its architecture and their mode of action remain largely unknown. New technologies, such as Hi-C, and developments in microscopy have revealed the complexity of the genome 3D architecture and its deep connections with gene regulation. By combining machine learning methods and polymer physics we infer, starting from experimental data, the specific genomic location of the distinct binding sites whereby DNA contacts are spontaneously established by the action of their cognate binding factors through only physics. Massive parallel simulations and efficient computational algorithms are then essential instruments to investigate the capability of our model to explain the experiments. In this talk I will discuss some key aspect behind our model, showing how it can be used to accurately describe real genomic loci and the effects of disease-linked genetic mutation on the DNA spatial organization. --- Per favore non rispondere a questo E-mail. In caso di necessita utilizzare http://gridticket.enea.it per contattare gli amministratori di eneagrid/CRESCO Informazioni su eneagrid/CRESCO sono disponibili a http://www.eneagrid.enea.it e http://www.cresco.enea.it --- Please do not reply to this E-mail. In case use http://gridticket.enea.it to contact eneagrid/CRESCO administrators See http://www.eneagrid.enea.it and http://www.cresco.enea.it for information about eneagrid/CRESCO =========== This message is sent to you because you are subscribed to the mailing list . To unsubscribe, E-mail to: but please take care that the membership to the list is required to have access as an user to ENEAGRID/CRESCO computational resources. To contact ENEAGRID/CRESCO administrators please submit a ticket to http://gridticket.enea.it/ 1 of 1 18/02/19, 10:10